Regenerative medicine and stem cell therapies hold much promise for the treatment of various injuries and diseases causing pain. Researchers are working on harnessing the process by which stem cells repair and replace damaged tissues and help to decrease the pain.
Back pain is a common problem that affects about 80% of people at some point during their life. The pain may range from a dull aching sensation to severe pain that makes getting out of bed impossible.
There are two types of back pain: acute and chronic.
Acute back pain is a short-term pain condition resulting from an injury or accident that lasts anywhere from a few days to a few weeks. Most back pain is acute.
Chronic back pain refers to back pain that lasts 12 or more weeks. This type of pain may develop after your acute back pain injury heals or from an underlying degenerative condition. If you suffer from chronic back pain and have tried multiple treatments without getting relief, schedule a consultation with the experts at Doctor’s G.
Almost half of all back pain causes are related to muscle contusion and strain. Muscle tissue is comprised of long, tubular cells called myoblasts, which fuse to form muscle fibers. Muscle stem cells, also known as satellite cells are responsible for muscle repair. During exercise, muscle fibers become damaged and send signals to satellite cells that sit on top of the muscle tissue. In response to these signals the satellite cells become activated, begin to divide, and as well as making copies of themselves, generate new myoblast cells. These myoblasts are then integrated and repair the damaged muscle tissue.
UCMSCs are adult stem cells which, as well as being able to produce copies of themselves, can divide and form bone, cartilage, muscle, and adipose cells when cultured in the appropriate conditions. MSCs produce proteins that are suggested to alter the surrounding environment and promote healing and tissue regeneration, such as anti-inflammatory factors, angiogenic factors (which promote the growth of new blood vessels) and other factors, which stimulate local, tissue-specific stem cells.
Most back pain develops from a mechanical problem that affects the structure and function of your back and spine. Common causes include:
- Sprains and strains
- Herniated or bulging discs.
- Arthritis.
- Degenerative disc disease.
- Vertebral compression fractures.
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About the treatment
Contrary to other Stem Cell treatments based on autologous transplant, where the stem cells are as old as the patient’s age and carry all the information accumulated through their life, at Doctor G®, we use donor umbilical cord-derived mesenchymal stem cells (MSCs) instead of bone marrow or fat tissue-derived. In our laboratory, umbilical cord MSCs can undergo approximately twice the number of “doublings” as their adult-derived bone marrow or fat tissue counterparts. The overall hypothesis is that UCMS cells possess immune properties that would be permissive to allogeneic transplantation. For example, UCMS cells will suppress the proliferation of “stimulated” lymphocytes (immune suppression) and have reduced immunogenicity (e.g., would be poor stimulators of allogeneic lymphocyte proliferation).
Mesenchymal stem cells are progenitors for several connective tissue cell lineages, including bone, cartilage, muscle, fat, and bone marrow. As mesenchymal stem cells can target diseased organs, they may hold potential as vehicles capable of expressing and secreting proteins with therapeutic effects. These conditions are ailments and disorders in muscles, ligaments, and joints. Common examples include Rheumatoid Arthritis, degenerative disc disease, osteoarthritis, and various injuries like fractures and torn cartilage.
Doctor G® Stem Cell Procedures help overcome these conditions by extracting stem cells from the umbilical cord, then concentrating and culture the cells and injecting them into the damaged area to help the body heal naturally. Our Stem Cell Procedures can be used for a wide range of conditions and are the tool of choice for injuries, arthritis, and other conditions that may be more significant than those treated with conventional therapies.
According to our research, stem cells have self-renewal qualities which aid in reproducing cartilage and bone tissue cells, restoring joint function, and reducing pain. Scientists have discovered that stem cells and specifically allogeneic umbilical cord mesenchymal stem cells, are home to inflamed tissue and start producing anti-inflammatory agents. Usually, these cells are harvested from human umbilical cords donated after normal healthy births. This means that stem cell transplants could be used to treat some of the most common osteoarticular symptoms.
The injection typically takes place three weeks after the UCMSCs are extracted from the umbilical cord. During this time, cells are grown for approximately 15 days and then tested for quality assurance, including sterility testing and karyotype analysis to ensure no genetic abnormalities present in the stem cells. Once the UCMSCs have passed all safety and quality testing, you will be scheduled for the injection procedure. During the injection, the cultured cells are thoroughly tested for quality assurance and injected using guided imaging to ensure the most precise placement of cells into the injured area.
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